102-32-9 manufacturer in stock Supply 3,4-dihydroxyphenylacetic acid（DOPAC） CAS NO.102-32-9

3,4-Dihydroxyphenylacetic acid is an important metabolite when studying the behavior of the dopaminergic system. 3,4-Dihydroxyphenylacetic acid is a phenol isolated from Arbutus unedo. It has antioxidant activity and exhibits both superoxide dismutase-like and DPPH radical scavenging activities.

(3,4-dihydroxyphenyl)acetic acid is a dihydroxyphenylacetic acid having the two  hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine. It has a role as a human metabolite. It is a dihydroxyphenylacetic acid and a member of catechols. It derives from a phenylacetic acid. It is a conjugate acid of a (3,4-dihydroxyphenyl)acetate.

3,4-Dihydroxyphenylacetic acid is intended for Pharmaceuticals applications. All information about 3,4-Dihydroxyphenylacetic acid is provided in the MSDS. We deliver compounds with high purity levels and a comprehensive Certificate of Analysis. Connect to your member account to consult the documents.

3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine  formed through deamination by monoamine oxidase (MAO). DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice. DOPAC oxidation is catalyzed by α-synuclein and oxidized DOPAC binds to monomeric α-synuclein preventing fibrillation. In vivo, foot shock stress increases DOPAC levels relative to control by approximately 45% in the prefrontal cortex and by 15% in the olfactory tubercles and ventral tegmental area (VTA) in rats.