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L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.

Menthol is colorless, transparent hexagonal or needlelike crystals. It is crystallized from Chinese Mentha Arvensis.Menthol is industrially prepared by the catalytic and hydrogenation of thymol. It is widely used in food flavoring, especially the flavor preparation of sugar and beverage.

（–)-Menthol is a monoterpene that has been found in cornmint oil and has diverse biological activities. It inhibits acetylcholinesterase (AChE; K_i = 1.25 mM for the bovine enzyme). (–)-Menthol (1.6 mM) decreases expression of the genes encoding topoisomerase I, IIα, and Iiβ in, and cell viability of, SNU-5 gastric cancer cells. It is active against the plant pathogenic bacteria A. tumefaciens and E. carotovora (MICs = 2.5 and 4 µg/ml, respectively).(–)-Menthol (3-10 mg/kg) reduces acetic acid-induced writhing and increases latency to paw licking in a hot plate test in mice