price 3223-07-2 reasonable price manufacturers CAS NO.3223-07-2

An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - melphalan, the racemic mixture - merphalan, and the dextro isomer - medphalan; toxic to bone marrow, but little vesicant action; potential carcinogen.

Melphalan is an orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.