Buy 331-39-5 factory High quality low price CAS NO.331-39-5

Caffeic Acid is an endogenous phenolic phytochemical compound that exists in plants and many foods. A major metabolite product upon hydrolization of chlorogenic acid caffeic acid inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

A natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A cell-permeable, selective, non-competitive inhibitor of 5-lipoxygenase (ID₅₀ = 3.7 µM). Inhibits Cu²⁺-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.

• Product name

  Caffeic acid, NF-kappaB inhibitor

• Description

  Specific NF-κB inhibitor

• Biological description

  Specific NF-κB inhibitor (IC₅₀ = 8.8 μM). Antioxidant, immunomodulatory and anti-inflammatory effects in vitro and in vivo. Additionally inhibits HDAC (IC₅₀ = 0.85 mM). Blood-brain barrier permeable.

• Purity

  > 98%

• CAS Number

  331-39-5

• Chemical structure