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Caffeic acid has inhibitory effects on histamine-induced responses and the inhibitory effect of Caffeic acid is gradually increased when the concentration used for pretreatment is increased from 0.1 to 1 mM, similar to typical dose-dependent responses. Pretreatment of HEK293T-TRPV1 cells with 1 mM Caffeic acid results in significant inhibition of capsaicin-induced responses. When lower concentration of Caffeic acid is used, the inhibitory effect for capsaicin-induced responses is less evident. Calcium imaging experiments show that Caffeic acid incubation results in significant inhibition in histamine-sensitive dorsal root ganglion (DRG) neurons. Pretreatment with Caffeic acid (1 mM) results in a significant decrease in the percentage of responsive DRG neurons to histamine application from 12.5% to 2.1%. Pretreatment with 1 mM Caffeic acid dramatically blocks the allylisothiocyanate (AITC)-induced intracellular calcium increase in TRPA1-expressing cells. Caffeic acid is also able to block the AITC-induced activation of TRPA1[1].

Caffeic acid, Caffeic acid, molecular formula C9H8O4, molecular weight of 180.15, from the yellow crystal in a concentrated aqueous solution, from a dilute aqueous solution of a hydrate. Decomposition point 223 ~ 225° (softened at 194°). Slightly soluble in cold water, soluble in hot water and cold ethanol. It can be used safely in cosmetics and has a wide range of antibacterial and antiviral activities. It absorbs ultraviolet light. Low concentration that is to inhibit the skin type hair dye auxiliant, is conducive to enhance the intensity of color.